RESEARCH INNOVATION ADVANCEMENT

The research at the NDLR team spans multiple interdisciplinary fields and datasets. Although the research topics covered since the group's inception has been diverse, the team is now focused on the most relevant subjects at the forefront of hepatology and gastroenterology.

MALNUTRITION

Malnutrition is a well-recognized pathological condition by which there are significant and systemic nutrition losses that result in various clinical findings - including generalized sarcopenia, cachexic developments, and functional impairments; given the serious clinical development from malnutrition, it is important to evaluate the medical and procedural outcomes of patients suffering from malnutrition, in order that the hospital risks are well-delineated and life-saving nutritional interventions can be provided.

CIRRHOSIS

The NDLR research program intends to further enrich the clinical and research experiences in advanced liver disease and cirrhosis science - to further evaluate the cross-sectional and prognostic relationships between cirrhosis and other etiologic and pathological disorders, including cirrhosis and influenza infection, cirrhosis and nutrition, cirrhosis and operational procedures.

SURGICAL OUTCOMES

The NDLR program research includes cross-sectional investigations of postsurgical outcomes as they are impacted by various potential preoperative risk factors.

FRAILTY

Clinical frailty is the composite aggregate of geriatric variables that relate to physiological, functional, and cognitive impairments in the elderly, which is currently garnering more medical and scientific attention as a serious mediator of adverse medical and surgical outcomes. Therefore, we evaluate the impact of clinical frailty on various medical and operative endpoints, in order to improve the clinical recognition of frailty in inpatient settings and so that multidisciplinary, multimodal support can be provided to this particularly vulnerable population.

HEALTH DISPARITY ANALYSIS

Health disparity is non-idealistically prevalent in various fields of medicine – as an initial first step to amending these differences is identifying the health inequities that pervade the cultural and healthcare ecosystems in the US. In our group - we identify these health disparities through systemic cross-sectional evaluations of national databases, parsing data using race and socioeconomic statuses.

PRE AND POST TRANSPLANT PROGNOSIS

The NDLR research program intends to understand the prognostic correlation between pre and post-liver transplant recipient and donor risk factors and waitlisted or post-transplant candidate/recipient prognosis using a series of stepwise Cox-regression and cumulative hazards analyses. Furthermore, we use regression-based modeling strategies to prognosticate the outcomes using the identified risk markers.